Joseph Gabriele received his B.Sc degree from the University of Toronto, while his M.Sc. and Ph.D. degrees were received from McMaster University. During Joseph’s Ph.D. training he worked under the supervision of Dr. R.K. Mishra, focusing on molecular neuroscience and its implications in schizophrenia. He has received numerous awards including: a Canadian Institutes of Health Research (CIHR) studentship award in Pharmacology during his Masters degree; an NSERC Canada Graduate Scholarship during his Ph.D. training; an Ontario Mental Health Foundation Postdoctoral Fellowship and more recently, the International Congress on Schizophrenia Research, Young Investigator Award and Hamilton Health Sciences, New Investigator Award. Specifically, his research involved the cloning and characterization of a catecholamine-regulated protein in humans, which is specific to the central nervous system and blood. Further investigation revealed that this human CRP40 protein is also expressed in platelets and lymphocytes of human blood at both the mRNA and protein levels. Preliminary data has shown a significant reduction of human CRP40 mRNA expression in white blood cells of schizophrenia subjects relative to age-matched healthy controls.
Training at McMaster involved the use of many molecular biology techniques including:
- Northern and western immunoblotting
- Antisense and SiRNA experiments in rat models
- Microsurgeries using stereotaxic equipment
- Immunohistochemistry and immunocytochemistry
- Real-Time PCR
- Epigenetic analysis (DNA methylation)
In 2006 during his postdoctoral training, Joseph trained in a more clinical environment at Queen’s University, Kingston, Ontario under the direction of psychiatrist and World Health Organization (WHO) professor, Dr. A.N. Singh, in a project involving the metabolic side effects of antipsychotic medications in schizophrenia subjects. During this period, Joseph has also learned and performed numerous experiments using epigenetic protocols and with the encouragement of Dr. J. Bienenstock and Dr. B Christensen has begun collaboration with Dr. A. Petronis of the University of Toronto. Dr. Gabriele has recently been appointed as an Assistant Professor at McMaster University in the Department of Psychiatry and Behavioural Neurosciences, and his future goal is to be a translational researcher bridging basic scientists and clinicians, specifically in schizophrenia research. Joseph and Dr. Mishra are presently funded by the CIHR and Ontario Mental Health Foundation.